Research Articles
Fine-Tuning Single-Cell Foundation Models: A 2025 Guide for Robust Downstream Analysis in Biomedicine
Single-cell Foundation Models (scFMs), pretrained on millions of cells, are revolutionizing the analysis of cellular heterogeneity and function.
Benchmarking Clinical Cancer Outcomes with Real-World Data: A Comprehensive Framework for scFM Validation and Global Equity
This article provides a comprehensive framework for benchmarking single-cell functional medicine (scFM) models in clinical cancer outcomes using real-world data (RWD).
Beyond the Hype: A Practical Framework for Evaluating the Biological Relevance of Single-Cell Foundation Model Embeddings
Single-cell Foundation Models (scFMs) represent a paradigm shift in computational biology, promising to unlock deep biological insights from single-cell RNA sequencing data.
Single-Cell Foundation Models: The AI Revolution in Cell Biology and Drug Discovery
Single-cell foundation models (scFMs) are large-scale AI systems, pre-trained on millions of single-cell transcriptomes, that are revolutionizing the analysis of cellular heterogeneity.
Benchmarking Perturbation Effect Prediction: Protocols, Pitfalls, and Future Directions for Computational Biology
This article provides a comprehensive guide to benchmarking protocols for computational models that predict cellular responses to genetic and chemical perturbations.
Benchmarking Cell Type Annotation Accuracy: A 2025 Guide to Methods, Tools, and Best Practices
Accurate cell type annotation is a critical, yet challenging, step in single-cell RNA sequencing analysis.
FBS Supplier Comparison for Contamination Testing: A Guide to Ensuring Reproducibility and Cell Culture Safety
This article provides researchers, scientists, and drug development professionals with a comprehensive framework for evaluating and selecting Fetal Bovine Serum (FBS) suppliers based on rigorous contamination testing protocols.
Strategic Reduction of Antibiotic Use: A Research and Development Framework for Combating Antimicrobial Resistance
This article provides a comprehensive analysis for researchers and drug development professionals on the critical role of reducing antibiotic use in mitigating antimicrobial resistance (AMR).
PCR vs. Culture for Mycoplasma Testing: A Strategic Guide for Biopharmaceutical Quality Control
This article provides a comprehensive analysis for researchers and drug development professionals on selecting between PCR and culture-based methods for mycoplasma testing.
What Causes Cell Culture Contamination? A Complete Guide to Sources, Prevention, and Control
Cell culture contamination is a critical challenge that compromises experimental integrity, data reproducibility, and patient safety in biopharmaceutical production.