Research Articles
Advanced Cell Type Annotation: A Multi-Model Integration Strategy for Precision Single-Cell Analysis
This article provides a comprehensive guide to multi-model integration strategies for cell type annotation, addressing the critical need for accuracy and robustness in single-cell genomics.
Developing Robust MoA-Aligned Potency Assays: A Comprehensive Guide for Biomarker and Matrix Strategy
This article provides a comprehensive framework for researchers and drug development professionals to establish robust, mechanism-of-action (MoA)-aligned potency and characterization matrices.
Mastering Matrigel Protocols: A Complete Guide to Optimized 3D Spheroid Models for Drug Discovery
This comprehensive guide provides researchers and drug development professionals with essential knowledge and practical protocols for establishing and optimizing 3D aggregated spheroid models using Matrigel.
Automated Cell Type Annotation: A Comprehensive Guide for Single-Cell RNA-Seq Analysis
This article provides a comprehensive guide to automated cell type annotation methods for single-cell RNA sequencing (scRNA-seq) data, tailored for researchers, scientists, and drug development professionals.
Beyond the Basics: Advanced Strategies to Resolve Ambiguity in Single-Cell Annotation of Similar Subtypes
This article provides a comprehensive guide for researchers and drug development professionals facing the critical challenge of accurately annotating highly similar cell subtypes in single-cell RNA sequencing (scRNA-seq) data.
LICT for LLM-Based Cell Type Identification: A Complete Framework for Researchers
This article provides a comprehensive guide to implementing Label-Independent Cell Typing (LICT) for Large Language Model (LLM)-based single-cell RNA sequencing (scRNA-seq) annotation.
Sequencing Platform Bias: How Your Technology Choice Shapes Single-Cell RNA-seq Cell Type Annotation
Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to deconstruct cellular heterogeneity.
Assessing MSC Potency with IL-1RA Secretion: A Critical Assay for Immunomodulatory Cell Therapy Development
This comprehensive guide for researchers and drug development professionals details the implementation and significance of the IL-1RA secretion assay as a critical quality attribute (CQA) for mesenchymal stromal cell (MSC)...
How to Validate Cell Type Annotations in scRNA-seq: A 2024 Guide for Biomedical Researchers
This article provides a comprehensive, step-by-step guide for researchers and drug development professionals on validating single-cell RNA sequencing (scRNA-seq) cell type annotations.
SingleR Cell Annotation Guide: From Theory to Practice for Precision Single-Cell Analysis
This comprehensive guide provides researchers, scientists, and drug development professionals with a complete workflow for using SingleR, the reference-based algorithm for automated cell type annotation of single-cell RNA-seq data.