Research Articles
Cell Type Annotation 2025: From Foundational Concepts to AI-Driven Validation in Single-Cell Research
This article provides a comprehensive guide to cell type annotation for researchers and drug development professionals.
Single-Cell Genomics: Revolutionizing Drug Discovery from Target Identification to Clinical Development
This article provides a comprehensive overview of single-cell genomics and its transformative impact on drug discovery and development.
Single-Cell Foundation Models (scFMs): A 2025 Guide to Applications, Benchmarks, and Future Directions
Single-cell foundation models (scFMs) represent a paradigm shift in computational biology, leveraging large-scale deep learning on massive single-cell datasets to create versatile tools for analyzing cellular heterogeneity.
Single-Cell RNA Sequencing Analysis: A Comprehensive Guide from Fundamentals to Clinical Applications
This article provides a comprehensive overview of single-cell RNA sequencing (scRNA-seq) analysis, addressing the complete workflow from experimental design to clinical translation.
Cross-Species Cell Annotation Foundation Models: A New Paradigm for Decoding Evolutionary Biology and Disease
Cross-species cell annotation foundation models represent a transformative advance in single-cell biology, enabling the deciphering of universal gene regulatory mechanisms across evolution. This article explores how AI models like GeneCompass, TranscriptFormer, and CAME leverage vast datasets from multiple species to accurately identify cell types, predict disease states, and simulate cellular behavior. We examine the foundational principles, methodological architectures, optimization strategies, and validation frameworks that underpin these tools. For researchers and drug development professionals, this synthesis provides critical insights for applying these models to translate findings from model organisms to human biology, accelerating the discovery of disease mechanisms and therapeutic targets.
Bioinformatics Unlocks Tirofiban's New Role in Fighting Stroke Inflammation
Discover how bioinformatics reveals tirofiban's dual mechanism in treating ischemic stroke - from anti-clotting to immune modulation.
Cracking the Cell's Code: A New Shortcut to Predict Drug Effects
How a smart AI named ScAPE is learning the language of life to accelerate medicine and predict transcriptomic responses to perturbations.
Unraveling Nature's Pharmacy: Transforming Medicinal Plants into Modern Therapeutic Agents
Explore how modern science is decoding nature's botanical secrets to develop innovative therapeutic agents from medicinal plants.
Beyond Pain Relief: How Common Anti-Inflammatory Drugs Interact with Your Cell Membranes
Explore how NSAIDs interact with cell membranes beyond COX inhibition and their effects on lipid peroxidation in inflammatory conditions.
Unlocking the Cell: A Stainless Steel Revolution in Drug Delivery
Discover how a simple stainless steel filter combined with viscoelastic fluids is revolutionizing intracellular drug delivery with unprecedented efficiency and cell viability.