Research Articles
Cost-Effective 3D Cell Culture: Strategies for Affordable Plate Alternatives and Workflow Optimization
This article provides a comprehensive guide for researchers and drug development professionals seeking to implement or scale three-dimensional (3D) cell culture while managing significant cost barriers.
Standardized Protocols for Reproducible Spheroids: A Guide for High-Throughput Screening and Disease Modeling
This article provides a comprehensive guide for researchers and drug development professionals on establishing standardized and reproducible spheroid models.
Overcoming the Hurdles: Key Challenges in 3D Cell Culture Assay Development for Predictive Drug Discovery
This article provides a comprehensive analysis of the major challenges stalling the widespread adoption of 3D cell culture assays in drug development.
Breaking Barriers: Advanced Strategies to Enhance Reagent Penetration in 3D Tumor Spheroids
This article provides a comprehensive guide for researchers and drug development professionals on overcoming the critical challenge of reagent penetration in 3D tumor spheroids.
Organoid Generation from Pluripotent Stem Cells: A 2025 Guide for Advanced Disease Modeling and Drug Development
This article provides a comprehensive overview of the current state and future directions of organoid generation from human pluripotent stem cells (hPSCs).
Preventing Spheroid Aggregation in Culture: A Complete Guide for Consistent 3D Models
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to understanding, preventing, and managing unwanted spheroid aggregation in 3D cell culture.
Optimizing Imaging for 3D Cell Cultures: Overcoming Challenges from Spheroids to Organoids
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to advanced imaging techniques for 3D cell cultures.
3D Bioprinting for Cell Culture: Techniques, Applications, and Future Directions in Biomedical Research
This comprehensive review explores the transformative impact of 3D bioprinting on cell culture applications, addressing the limitations of traditional 2D models.
Advanced Co-Culture Techniques for Modeling Tumor-Stroma Interactions: From 3D Models to Clinical Translation
This article provides a comprehensive overview of advanced co-culture techniques for modeling the dynamic interplay between tumor cells and the stromal microenvironment.
A Comprehensive Guide to Generating Uniform Spheroids in U-Bottom Plates: From Basic Principles to Advanced Applications
This article provides researchers, scientists, and drug development professionals with a complete methodological framework for generating and analyzing multicellular tumor spheroids (MCTS) using U-bottom plates.