Research Articles
A Researcher's Guide to Automated Cell Type Annotation in 2025: From Foundations to LLMs
This guide provides researchers and drug development professionals with a comprehensive tutorial on automated cell type annotation tools for single-cell RNA sequencing (scRNA-seq) data.
Advanced Strategies for Novel and Rare Cell Type Annotation: From LLMs to Spatial Mapping
Accurately annotating novel and rare cell populations remains a significant challenge in single-cell RNA sequencing analysis.
Manual vs Automated Annotation in Drug Development: A Strategic Guide for Researchers
This article provides a comprehensive analysis for researchers and drug development professionals navigating the critical choice between manual and automated data annotation.
Unlocking Cellular Heterogeneity: The Essential Role of Clustering in Single-Cell RNA-Seq Cell Type Identification
This comprehensive review explores the critical role of unsupervised clustering in single-cell RNA sequencing for cell type identification, addressing both foundational concepts and cutting-edge methodologies.
Decoding Cellular Heterogeneity: A Comprehensive Guide to scRNA-seq Data Analysis for Biomedical Research
Single-cell RNA sequencing (scRNA-seq) has revolutionized biomedical research by enabling the precise dissection of cellular heterogeneity, revealing previously hidden cell types, states, and dynamics within tissues.
Decoding Cell Identity and State: A Comprehensive Guide for Biomedical Research
This article provides a comprehensive overview of the modern frameworks and technologies used to define cell identity and states, crucial for advancing drug development and disease research.
Marker Gene Databases for Single-Cell Annotation: A Comprehensive Guide for Researchers
This article provides a comprehensive overview of marker gene databases and their pivotal role in single-cell RNA sequencing (scRNA-seq) data annotation.
Cell Type Annotation in Single-Cell RNA Sequencing: From Foundational Concepts to AI-Powered Methods
Cell type annotation is a fundamental yet challenging step in single-cell RNA sequencing (scRNA-seq) analysis, bridging computational clustering results to biological meaning by identifying the cell types present in a...
Manual Cell Type Annotation Best Practices 2025: A Researcher's Guide to Accurate Single-Cell Analysis
This comprehensive guide provides researchers and drug development professionals with current best practices for manual cell type annotation in single-cell RNA sequencing data.
Viral Vector Structure-Function Studies: From Molecular Architecture to Clinical Application
This article provides a comprehensive analysis of viral vector structure-function relationships, bridging fundamental virology with therapeutic development.