Research Articles
3D Cell Culture: A Foundational Guide for Researchers and Drug Development Professionals
This article provides a comprehensive introduction to three-dimensional (3D) cell culture, a transformative technology offering more physiologically relevant in vitro models.
Spheroids vs. Organoids: A Comprehensive Guide to Advanced 3D Cell Culture Models
This article provides researchers, scientists, and drug development professionals with a definitive guide to three-dimensional (3D) cell culture models.
Bridging the Gap: How 3D Cell Culture Accurately Mimics the Tumor Microenvironment for Advanced Cancer Research
This article explores the pivotal role of three-dimensional (3D) cell culture technologies in replicating the complex tumor microenvironment (TME), addressing a critical gap in preclinical cancer research.
Scaffold-Based vs. Scaffold-Free 3D Cell Culture: A Comprehensive Guide for Advanced Research and Drug Development
This article provides a detailed comparative analysis of scaffold-based and scaffold-free three-dimensional (3D) cell culture systems, essential tools for researchers and drug development professionals seeking more physiologically relevant in vitro...
Expert vs. Automated Annotation: A Framework for Consistency Evaluation in Biomedical AI
This article provides a comprehensive framework for researchers and drug development professionals to evaluate the consistency between expert and automated data annotations, a critical bottleneck in building reliable AI models...
Beyond the Monolayer: How 3D Cell Culture is Revolutionizing Predictive Drug Discovery and Disease Modeling
This article provides a comprehensive analysis for researchers and drug development professionals on the paradigm shift from traditional 2D to physiologically relevant 3D cell culture.
Manual vs. Automated Annotation: A Precision-Focused Analysis for Biomedical AI
This article provides a comprehensive comparison of manual and automated data annotation accuracy, tailored for researchers and professionals in drug development and biomedical science.
VICTOR: A Comprehensive Guide to Assessing Cell Type Annotation Quality in Single-Cell RNA Sequencing
This article provides a detailed exploration of VICTOR (Validation and Inspection of Cell Type Annotation Through Optimal Regression), a novel method for gauging the confidence of automated cell type annotations...
Benchmarking Traditional vs. AI Annotation for Drug Discovery: A 2025 Guide for Biomedical Researchers
This article provides a comprehensive benchmark analysis for researchers and scientists in drug development, comparing traditional manual and modern AI-powered data annotation methods.
Beyond the Hype: A Practical Framework for Validating LLM-Based Cell Type Annotations with Marker Gene Expression
The integration of Large Language Models (LLMs) into single-cell RNA sequencing analysis promises to revolutionize cell type annotation by reducing manual labor and leveraging vast biological knowledge.